Currently there is a paucity of robust evidence for the use of blood biomarkers in COVID-19 diagnosis, therefore it is proposed that an extensive list of biomarkers is recorded during the diagnostic accuracy evaluations of the new COVID-19 tests in the summer months in order to help bridge this knowledge gap. The University of Manchester, Manchester, M13 9PLĬorrespondence to aim is to develop a composite reference standard for COVID-19 diagnosis that will support a standardised approach across research groups to decrease the high false negative rate of rRT-PCR that could penalise the evaluation of diagnostic accuracy of new tests if rRT-PCR is used as a stand-alone reference standard. Newcastle University, Newcastle upon Tyne, NE2 4HHģDivision of Cardiovascular Sciences, The University of Manchester Newcastle upon Tyne NHS Hospitals Foundation TrustĢNIHR Newcastle In Vitro Diagnostics Co-operative
Ashley Price 1, Richard Body 3ġNIHR Newcastle In Vitro Diagnostics Co-operative A Composite Reference Standard for COVID-19 Diagnostic Accuracy Studies: a roadmap
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